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Fecal Microbiota Transplant Questions and Answers

fecal transplant common questions

Question 1:  What are the main requirements to be a good Fecal Transplant Donor?

Dr. Mark Davis Fecal Transplant ProviderHealth: I suggest the Fecal Microbiota Transplantation Workgroup criteria as the baseline for determining a good donor. That means no infectious disease, autoimmune disease, gastrointestinal disease, atopic disease, blood sugar dysregulation, mood disorders, or chronic pain, and lab tests showing the donor to be negative for blood and fecal transmissible pathogens. I’ve had patients decide to skip the lab tests when they’re using a parent, child, or spouse as a donor and they feel confident that they don’t have risk factors for any of the things the lab tests look for. In addition, you’re looking for someone who has a formed bowel movement every day or almost every day, and who hasn’t had antibiotics in at least 3-6 months. Ideally you want a donor who has generally clear skin, healthy energy and activity levels, and a good disposition.

Age: Conventional wisdom is that kid colon flora resembles adult flora by age two, and that colon flora diversity declines in elderly populations, so the best donors will probably be between the age of two and sixty-five. That being said, I’ve seen people benefit when using FMT donors younger than two, and there’s no evidence (just speculation) that individuals over the age of sixty-five won’t make effective donors.

Family members: I’ve seen people with Ulcerative Colitis, C diff colitis, and other conditions benefit from family member donors and unrelated donors. No clear evidence yet, but my guess is that it doesn’t make a difference.

Blood type: There’s one paper (http://www.biomedcentral.com/content/pdf/1471-2180-12-94.pdf) suggesting that people who have blood type “B” or “AB” may have a significantly different gut microbiome than people who don’t, so in my practice I’ve recently started trying to pair donors and patients with compatible blood types, but it’s way too early to see if that’s making any difference.

Dr. Neil Stollman MD GastroenterologistAge is really an unknown, but clearly infants are ‘different’ from adolescents and adults, who are typically used, although more by convention than based on science. Likewise, family members are often used as they are willing confidantes, but whether that’s more effective is unknown. Intimate partners are generally the most desirable, in that if they do have an undiagnosed potentially transmissable infection, they’ve essentially already shared it, and it’s quite unlikely that a transplant exposes the recipient to any additional risk.

Question 2:  When treating C-difficile, how many and at what intervals are fecal transplants necessary?

Dr. Mark Davis Fecal Transplant ProviderThere was a great meta-analysis (http://cid.oxfordjournals.org/content/53/10/994.long) that tried to answer that question. This chart (http://cid.oxfordjournals.org/content/53/10/994/T2.expansion.html) from that paper indicates that groups that gave one infusion saw an 81.7% resolution without relapse rate. Groups that gave two or three infusions had a 91.2% resolution without relapse rate. Groups that gave more than three infusions had an 87.2% resolution without relapse rate.

The way I use that information clinically with C diff colitis patient is to give an initial FMT infusion, and check in 24 hours later. If someone is 95-100% better, I tell them they’re done. If they’re less than 95% better, we do a second infusion, and check in again after 24 hours. I’ve had to administer as many as five infusions that way.

Dr. Neil Stollman MD GastroenterologistExtensive data supports that one transplant is sufficient (and effective) in the large majority of C diff patients. There’s no data (but probably no need for such data) on multiple transplants in this population. Most series have used a single implant, from a single donor, most often an intimate partner, with ‘cure’ rates of >90%.

Question 3:  What is the most effective way to deliver a fecal transplant? (Colonoscopy, enema, endoscopy etc..?)

Dr. Mark Davis Fecal Transplant ProviderGreat question. The comparison chart (http://cid.oxfordjournals.org/content/53/10/994/T2.expansion.html) from the meta-analysis I mentioned in the previous question does it’s best to answer that question as well, and enema came up as he most effective technique! I want to emphasize here that the whole meta-analysis only looked at 317 patients, so I’m not convinced that enema-delivered FMT really is tremendously more effective for C diff colitis than colonoscopically-delivered FMT is, but it certainly doesn’t seem LESS effective.

Since I’m writing these answers for “IhaveUC.com” though, I want to address efficacy for UC. This question has never been examined, since there are so few people treating UC with FMT. The main doc providing FMT for UC is Thomas Borody, an Australian gastroenterologist, and he uses a colonoscope; he only published about his findings in 2003/2004, at which time he reported a 50% effectiveness rate, although he’s told me he’s seeing FMT be effective for UC about 90% of the time now. In my practice, I’m seeing no benefit in about 10% of UC patients, partial benefit in 60-70%, and complete effectiveness (no symptoms no meds, and eating a varied diet) about 25% of the time. That’s not nearly as good as Dr. Borody is reporting, and I wonder if it’s because we are reporting our successes differently or because he is administering via colonoscope.

I’ve seen complete turnarounds of UC (people with 10+ bloody BMs/day, some people with UC for decades) using enema-delivered FMT, but I wonder if some of my patients who improved partially (symptom free as long as they avoid certain foods or stay on certain meds, or off meds and eating a varied diet with most symptoms gone, but still experiencing at least one symptom) might have improved more with colonoscopically-delivered FMT, so I’m training in colonoscopy, and hope to be able to offer it to patients in summer of 2013, although it might be longer than that.

Dr. Neil Stollman MD GastroenterologistAlso not definitively known, and there’s plenty of data supporting quite high cure rates with all three routes. Clearly, as a gastroenterologist, colonoscopic administration is available to me, and intellectually makes sense. Upper tract administration (NG tube or endoscopy) seems to have modestly lower cure rates in a global (not statistical) analysis, and is esthetically unappealing to many, as well as potentially exposing the infusate to acid, bile salts, pancreatic enzymes etc, which could have unknown effects. Enema cure rates seem quite reasonable as well. To a man with a hammer…..

Question 4:  Can fecal transplants work for people who have a j-Pouch?

Dr. Mark Davis Fecal Transplant ProviderThere aren’t any cases in the published scientific literature of using FMT for people with a J-pouch, and I haven’t used FMT anyone with a J-pouch in my practice either. However, since pouchitis can respond to oral probiotics (http://www.ncbi.nlm.nih.gov/pubmed/12730861?dopt=Abstract), it seems likely that changing the pouch microbiome with FMT has potential to benefit people with recurrent pouchitis.

Dr. Neil Stollman MD Gastroenterologist

 

unknown (to me, at least)

 

Question 5:  Is it recommended to take antibiotics prior to starting fecal transplant therapy?

Dr. Mark Davis Fecal Transplant ProviderAnother great question. Dr. Borody. who’s the most experienced doc in the world at using FMT for UC, gives antibiotics before FMT for every UC patient. The idea makes sense: try to decrease the amounts potentially harmful bacteria we don’t want in there so they are more easily outcompeted by the healthy bacteria that we’re introducing with FMT. Since Dr. Borody uses them for all his patients though, I didn’t know before I got started how important of an ingredient that was to the success of his FMT infusions. I’ve prescribed Dr. Borody’s protocol (metronidazole, vancomycin and rifampin) to some of my UC patients before FMT, used different anti-biotic pretreatment protocols for others, tried herbal antimicrobials with some, and used no antimicrobial pretreatment with about half of the UC patients I’ve tried FMT with. I’ve seen successes and failures in each of these groups, and although I haven’t carefully analyzed my own clinical data yet, I don’t think I’m seeing more success in the antibiotic pre-treatment group.

There aren’t any studies that have looked at this in humans, but there is one group (http://genome.cshlp.org/content/20/10/1411.long) who has studied this in rats: they did FMT with a number of rats, and used a very accurate DNA-measuring technique to look at their colon flora before and after the treatment, while comparing it to the colon flora of their donors. They also gave half of the rats antibiotics first. They concluded that “antibiotic pretreatment counter-intuitively interferes with the establishment of an exogenous community.”

In my practice I’m willing to prescribe the antibiotic pretreatment (since it’s part of the world’s most respected protocol) but I encourage people to consider trying it without the antibiotics, since of course those have some risks of their own.

Dr. Neil Stollman MD Gastroenterologist

 

I don’t believe so, although there are many opinions on same, and little data.

 

Question 6:  How effective are fecal transplants for helping patients treat Ulcerative Colitis and Crohn’s Disease?

Dr. Mark Davis Fecal Transplant ProviderDr. Borody initially reported a 50% success rate in using FMT for a mixed IBD and IBS population ( PDF File Link to this study), and more recently has told me in conversation that he’s seeing complete resolution in 90% of the UC patients that he uses FMT with, as long as they are able to re-infuse for long enough. In my own practice (treating about 40 UC patients with FMT in the past year) I’m seeing no benefit in about 10% of UC patients, partial benefit in 60-70%, and complete effectiveness (no symptoms no meds, and eating a varied diet) about 25% of the time.

For Crohn’s, a lot less is known. Dr. Borody has reported using FMT with one patient with Crohn’s colitis, who became symptom free without meds or dietary restrictions for 18 months, then relapsed. I treated one patient with Crohn’s who had previously had most of his colon and parts of his small intestine resected. He did not see any benefit from FMT.

Dr. Neil Stollman MD Gastroenterologist

 

Also still very limited and early data. It’s certainly plausible that they might be, but as compared with the data for c diff, which to me is conclusive, this is still a very unsettled question.

 

Question 7:  What might be some of the reasons that Fecal Transplants work for some people and not for others?

Dr. Mark Davis Fecal Transplant ProviderThat is the million dollar question. I don’t know. For some people, maybe their colon bacteria are not the primary trigger of their autoimmune colon inflammation, and FMT will never work for them. Other people may be using a non-compatible donor. For people that it could work for but hasn’t, I’m starting to think more and more that persistence is the key, just frequency of infusions until symptoms are well-managed, then gradually tapering. Some people who don’t benefit when trying FMT without pre-treatment via enema may benefit with antibiotic pre-treatment or or colonoscopic delivery.

Dr. Neil Stollman MD Gastroenterologist

 

host biome? donor biome? technique? moon phase? (ie, who knows)

 

Question 8:  What are some of the risks involved with trying Fecal Transplant Therapy?

Dr. Mark Davis Fecal Transplant ProviderI always tell people that the major literature reviews on the subject call the side effect profile of enema-delivered FMT from a properly-screened donor “none” or “negligible.” That being said, FMT isn’t approved by the FDA for any indication, and the biggest review to date has only included 317 patients, so there’s a lot we don’t know. FMT delivered by naso-gastric tube or colonoscope carries the small but real risk of perforation, peritonitis, or bad reaction to anesthesia. There are a list of health problems we associate with colon flora that currently make us exclude donors (asthma, eczema, IBS, colon cancer, any autoimmune disease) but it could be possible that there are other conditions we don’t know to exclude that are associated with gut flora, and that could be transmitted.

Dr. Neil Stollman MD GastroenterologistWe haven’t really seen much morbidity or harm, but it’s still early, and still unknown. There is certainly a theoretical risk of infection transmission (Hepatitis C, for example, has been transmitted via colonoscopy, ostensibly a much lower viral load), although I’m unaware of any reports to date. Also, we’ve really got no clue how durable the ‘biome transformation’ is, and if it is durable, could that have adverse immunologic or metabolic consequences? it absolutely could, but we just can’t tell yet.

Question 9:  What costs might a patient expect to incur if insurance did not cover Fecal Transplant Therapy?

Dr. Mark Davis Fecal Transplant ProviderIf they live with an eligible donor, and they are willing and able to do the preparation and administration themselves, it can cost under $100 for a blender, some enema bottles, a strainer, etc. If they want colonoscopic delivery (from Dr. Lawrence Brandt in New York or Dr. Alister George in California), it’s just the cost of the colonoscopy, which I think is a thousand or two.

If someone with C diff colitis does not have a donor, Dr. Alex Khoruts in Minnesota and myself (Mark Davis in Oregon) maintain fecal slurry donor banks form pre-screened donors. I also use my donor bank to treat patients with UC. People with UC who use my donor bank and are able to self-administer the enemas pay $4,050 for ten days, plus $200 per infusion for re-infusions if they are indicated.

Dr. Neil Stollman MD Gastroenterologist

 

Very variable. the procedure itself costs might be minimal for enemas, certainly higher for colonoscopy. The costs of donor screening can be substantial as well. the disposable blender from target is the least of it!

Question 10:  I have dysbiosis of the large bowel and chronic SIBO in the small intestine. Would a fecal transplant help rectify the colonic bacteria in both the small and large intestine?

Dr. Mark Davis Fecal Transplant ProviderGreat question! I used to tell people routinely that I didn’t think FMT could help SIBO or other dysbioses of the small bowel. Now that I’ve started having some success treating patients with chronic constipation though, I’m realizing that sometimes SIBO can occur as a RESULT of large bowel constipation and other dysbiosis, and once you clear up what’s going on in the large bowel, you can see small bowel problems resolve as well.

Dr. Neil Stollman MD Gastroenterologist

 

completely unknown

 

Question 11:  If you tested positive for C-diff, would you first take antibiotics to treat the C-diff, or would you opt to try fecal transplant therapy first?

Dr. Mark Davis Fecal Transplant ProviderI personally would definitely try FMT first. Most docs who use FMT for C diff keep their patients on doses of antibiotics large enough to keep them sypmtom-free until they infuse the fecal slurries, but I did treat one patient who was not on any antibiotics at the time who had a complete resolution after FMT.

Dr. Neil Stollman MD GastroenterologistCertainly the national standard of care is currently first to take antibiotics, and apply transplant to multiply-recurrent patients. SHOULD that be the standard? Would i personally do differently? At this point, I think it is a rational and data supported standard, and no, I probably wouldn’t personally try transplant first.

 

Question 12:  Is the medical community expecting for fecal transplant therapy to become more popular and accepted as a viable option for more GI related health problem? (Besides C-diff)

Dr. Mark Davis Fecal Transplant ProviderYes! The main reason that many gastroenterologists are not routinely performing FMT is that their hospital or clinic administrators will not allow them to perform a procedure that has not been shown to be safe and effective in a randomized controlled trial. There are currently two trials of FMT for UC underway, one in Toronto for Canadian adults with UC (http://clinicaltrials.gov/ct2/show/NCT01545908) and the other in Michigan for children with colonic IBD (http://clinicaltrials.gov/ct2/show/NCT01560819?term=NCT01560819&rank=1). The trial for adults is giving one enema-administered infusion per week for six weeks, and the trial for children is giving five infusions within the span of ten days. Now, neither of these duration/frequency protocols is what I would have chosen, but I’m hoping they see positive results, because if they do I expect to see many more gastroenterologists in the US and world-wide performing FMT for UC.

Dr. Neil Stollman MD Gastroenterologist

 

Absolutely. Huge buzz from this and the human biome project. all that’s left to figure out is, you know, well, who, what, why, when and how? ie EVERYTHING! it’s an exciting early stage and it will be fascinating to me to see how this all evolves over the next decade.

 

Question 13:  Additional Comments/Ideas regarding Fecal Stool Transplants…

Dr. Mark Davis Fecal Transplant ProviderI’ve been exploring some other untested ideas, some drawn from Dr. Borody, some from the naturopathic community. Sometimes I recommend a short course of prednisone just before and during the infusions period, and I usually recommend DHEA with prednisone. For UC patients I usually suggest a period of low to no fibre before starting FMT, then introduce fiber foods starting with the infusions. If people are using antibiotics or other antimicrobials I suggest using a bifilm disruptor–I most often use NAC.

 

 

 

 

Bright Medicine Clinic

Dr. Mark Davis
5432 N Maryland Ave
Portland Oregon 97217
phone 971.800.1368
fax 971.239.1913
info@brightmedicineclinic.com
www.probioticinfusion.com

 

Dr. Neil Stollman MD Gastroenterologist

 

 

Neil Stollman MD, AGAF, FACP, FACG
Chairman, Department of Medicine
Alta Bates Summit Medical Center
Oakland, CA
Associate Clinical Professor of Medicine
Division of Gastroenterology
University of California San Francisco
www.norcalgi.com

 

 

(On behalf of the iHaveUC readers and Colitis Patients of the world, I’d like to send a Huge Thank You to Dr. Davis and Dr. Neil Stollman for taking so much time to answer all of the user submitted questions.  And to everyone reading, please note that Dr. Davis volunteered his time for this Q&A session and has received no monetary compensation from the iHaveUC.com site.  Dr. Davis wrote another informational story on the site back in November of 2011 which you can also read via this link:  Fecal Transplant Info which has quite a few comments and additional answers.

Also, just so everyone knows, Dr. Neil Stollman is my personal GI doctor – and an amazing person too.  I’ve written about him before, and he appeared on the video I shot a few months ago sharing my colonoscopy results.  I can’t thank him enough for participating here as well.  Like Dr. Davis, he has received no monetary compensation from the iHaveUC site for his time and effort in participating with this Fecal Q&A project.)

Like always, please feel free to leave your comments below, and feel free to share or forward this valuable information to anyone else who might have questions about this type of therapy.  Thank you as well to everyone who submitted your questions.  I tried my hardest to include all of your questions that I felt would benefit as many people as possible, however there were some very specific questions that some of you wrote which were not included (and I apologize for that).  If that was one of you, post your questions in the comment area below with the hope that an answer will follow.

-Adam Scheuer

PS: here is a video which might answer some more of your questions that you still may.  It focuses specifically on Fecal Transplant Therapy for C-Difficile:


Update Recent News (as of January 2013): And if you just really have not gotten enough about Fecal Transplants and C-DIFF, there’s some more news about the effectiveness here in a new “Fecal Transplant Microbiome Breakthrough Study

Tags: c-diff, Dr Mark Davis, Dr. Neil Stollman, fecal transplant, FMT





29 Responses to “Fecal Microbiota Transplant Questions and Answers”

  1. joannaDecember 22, 2012 at 5:40 pm #

    ah such a great post, adam! i’m so glad i got to read it. i tried 8 fecal transplants via enema but didn’t see any improvement- actually went from 7 bms a day to 15-20 bms. i always figured it was because my donor and i weren’t compatible. i know we were both blood type A, but we had very different diets and i think our gut bacteria just didn’t mesh. it would be interesting to see if i could benefit with a different donor or even through colonoscopy. i might try it again someday if humira doesn’t work or no new meds/therapies come out. it’s definitely a gross procedure for everyone involved but UC people get desperate!

    • KarolinaSeptember 24, 2013 at 2:53 am #

      H all

      Wow thanks for this. I am getting my FMT tomorrow in hospital. I’m soooo excited! I have to make the preparation at home…my doc gave me most of the directions…but I will be going under and getting it via endoscopy…pumped thru my small intestine. I read in a recent article that a group of researchers are working on synthetic poop. What was most interesting was that they don’t let the poop have time to mix with oxygen they say it kills lots of needed bacteria…I wonder if this may be a reason why this sometimes does not work…

      Anyhow wish me luck!

      Karolina (Ottawa, Canada)

  2. JaneDecember 22, 2012 at 6:53 pm #

    Glad to read this as my doctor tried to convince me it was NOT available for UC. i’m going to rub this in pretty good… I”m very annoyed with her, needless to say. She never even had me checked for C-Diff until i demanded it.

    Before I forget, I’ve had UC for 10 yrs and have used ZYFLAMEND LIQUID for 8 yrs which saved my life.
    I’m still pursuing the FMT, of course.
    When using Zyflamend LIQUID put it under the tongue, wash it down with any drink you like, (as it tastes bad) and use it 2x a day initially. It will work IMMEDIATELY. I now use it 1x a day. My repeat colonoscopy was the exact same 8 yrs apart.
    Zyflamend can be looked up on the net, new chapter makes it, and is sold world wide. I was very lucky to find it. Never been on medications, never changed my crappy diet either. Its also inexpensive, and the side effects are, faster growing hair, and strong nails too ;) Aside from all the other benefits.

    PS: I don’t think FMT is gross, that is a stigma that needs to be eradicated. I think as a (retired) dog breeder and seeing dogs eat feces out of instinct, they know something is missing in their gut and simply are replenishing it. I never stopped them from it, and they don’t always do it, so there must be a reason for the occasional munching on other dogs’ poop.

    Good Luck and thanks for this excellent post !!!

  3. bevDecember 23, 2012 at 9:31 am #

    Again, thank you Adam. So much info!

  4. AmosDecember 23, 2012 at 2:26 pm #

    Thank you so much, Adam for posting this. I talked with Dr. Davis about a year ago about FMT and although I never technically was a patient of his I was amazed at his knowledge, expertise, and passion for healing. He truly is a pioneer in this area (as is Dr. Borody) and I am so glad that more people are finding out about this therapy and am greatful that there are people out there like Dr Davis.

  5. shelly in maineDecember 23, 2012 at 4:12 pm #

    Wow…fascinating and still the “ick” factor especially with the thought of the home kit and the added visual/sound effects of the blender!! That is definitely not my power smoothie! But hopefully someone’s…keeping my fingers crossed for the nonfecal advances…that sounds pretty awesome to me-probiotics essentially directly where they need to go?!
    “Poo is a zoo!”Dr.B. & “10% human; 90% poo!” Great quotes, promising research…
    Thanks Adam and Dr. Davis….making my power Smoothies will never be the same! :-) :-) Shelly

    • joannaDecember 23, 2012 at 5:35 pm #

      shelly, when i did FT, i bought a separate blender for my poop solution. there was NO chance i was gonna use my vitamix haha but yeah, it’s definitely the grossest thing i’ve ever done. the smell is what gets you the most so having open windows and wearing a mask is a MUST.

      • shelly in maineDecember 23, 2012 at 7:47 pm #

        :-) so sorry…kudos to you for trying, but sorry it didn’t work. I think a hazmat suit is in order! I think the doc./nurse or whatever she was in the video almost looked like she was making a cringing face!

        When do you start humira? Make sure you read EVERYTHING about it. You probably read the post Adam did a while back on its approval? I’m not a fan/allergic, but I wish you tons of luck. I always kept benadryl on hand and write everything down!

        I am using herbs, probiotics, omegas, enzymes, vit d, aloe, spiruten and about 99% SCD- trying to get out of my second flare of being off meds for over a year! This one has been a tough one…but Keeping my fingers crossed and hoping to write a new positive story..,.almost have the bleeding stopped after about 3 months so there is great promise…I’ve been meaning to write you…so great “coincidence”?! :-) hang in there…
        Best, Shelly

        • joannaDecember 24, 2012 at 5:33 pm #

          hey shelly! i hope you get out of your flare soon! that is what i asked for christmas this year- well, mainly to magically wake up and not have UC. that would be AWESOME.

          as for humira, i faxed my nurse my TB results about 2 weeks ago and she said she’d request humira from my insurance as soon as i did that. still haven’t heard anything. it took about 3 weeks for me to get remicade so i figure it’s around the same wait. but yeah, i read adam’s humira thread and wanted to cry ahhh just gotta hope for the best. if i get bad side effects, i’ll just stop it. that’s what i’ve done with everything else and so far i haven’t had any long term effects.

          what enzymes are you on? i got some new digestive enzymes by klaire labs but im waiting to take them after my xmas party tomorrow. i didn’t want to be all gassy or crampy if the enzymes can do that.

          • shelly in maineDecember 25, 2012 at 4:50 am #

            Hi Joanna,
            The enzymes are Zypan…from my chiro. Same with the herbs. Plus, as you probably know, I take 4g of Lovaza, and Mega doses of the vsl 3 prescription strength…3-4 packets of 900 Billion!! I wanted to be more systematic, but as usual the flare came on fast and furious. The true SCD is a bit torturous! Found I had to give up all dairy at least for now. I know you had done some herbs…were those from a naturapath or? My chiro practices Chinese medicine-I can let you know what those herbs are if you want. I still have a long way to go…healing is VERY slow, but hopefully will continue after 30+ years no more toxic meds for me and the rest don’t work anymore or allergic!
            Oh, no j pouch where I live so added stress…great for uc!
            Enjoy your party!

    • shelly in maineDecember 24, 2012 at 6:26 am #

      Oops -And thanks Dr. Stollman, Dr. Borody, other researchers and anyone who has to run the blenders!

      • joannaDecember 28, 2012 at 9:30 pm #

        hey shelly! wow that is a lot of probiotics you take. the most i ever did was 2 packets of VSL DS a day but it was just ridiculously expensive. my insurance doesn’t cover it so a 20 day supply was $186. i just couldn’t afford it at all. i didn’t even notice a difference while i was on it or the regular VSL either. i tried enemas with it but no help there.

        yeah, i got the herbs from a naturopath. i can’t remember what supplements she gave me. i threw all of them away because i ended up in the hospital 3 days later. i was going about 30x a day after i started them.

        right now, i seem to average 4-5x a day which is fine with me. still need to fix some things but we’ll see what the humira does.

  6. anneDecember 24, 2012 at 1:38 am #

    I have seen Dr Borody and other doctors at the Centre of Digest Diseases, I had a colonscopy to confirm see if I have UC or crohns and a blood test to see if I have mycobacterium paratuberculosis which is the bug they believe is causing UC / Crohns in peopole. apparently the blood test is new and has never been able to be detected in humans. I am currently taking a course of antibiotics rifaximin(which is made by a compounding chemist) and flaygl, also prescribed Acetarsol suppositories(made by compounding chenist as well). I was told to continue taking my current medications methotrexate injections and prednisone as well I have only been on the antibiotics for 2 weeks now. I asked about FMT and was told they like to ensure that the colon is healthy before doing FMT as the good bacteria will adhere to the colon and gives a better result I also asked if I can get of the antibitoics and was told lets wait and see how I go. I have another appointment in february to see how I am going and have to have another colonscopy in 6 months time. the only problem is the mecications is very expensive the rifxamin is $100AUS not to mentioned all the other mecdication I am taking so I so hope this treatment is the cure / remission I am hoping for.
    regards to all
    Anne

    • anneDecember 24, 2012 at 1:45 am #

      ALSO was told if these current antibiotics do not work they have 12 other antibioctics that can be used. Dr Borody also said he cured himself from constipation doing FMT he said he got the constipation bug and curred himself I was also told that one of his patients who has crohns is “cured” after FMT and treatment. I am hopefull that this is the cure for us patients with UC and or /Crohns and that it is a bug that is causing the problem and can be eradicated, like helicobactyer pylori which was once thought was caused by stress to some doctor found that it was a bug.
      good health to all

      Anne

      • BeckyJanuary 20, 2013 at 2:06 am #

        Hi Anne, did you have Crohns or UC? And did you test positive for mycobacterium para tuberculosis? does Dr Borody believe that mycobacterium para tuberculosis is responsible for UC too? Does he treat UC with antibiotics? Thank you

        • anneOctober 1, 2014 at 6:27 am #

          Hi Becky appolgoise for late response to your questions. I have UC but when tested for MAP was told I had it. Dr borody advised me that MAP is only in crohns disease yet my scope he believes I have UC. so very confused about this.

          I was treated with antibitoics for my UC I hope this answer your questions.

      • EllaSeptember 29, 2014 at 7:50 pm #

        Hello Anne,
        Thank you for your post. I am also trying to meet Dr Borody. My daughter if fighting the desiase for almost 3 years. She is 16 y/o, having a hard time to adapt to a diet , and friquent exams in school, trips to a doctors….
        How re youdoing after FTM ? I hope it helped!
        PleSe right to me :
        Stella.corp@hotmail.com

        .

        • anneOctober 1, 2014 at 6:38 am #

          Hi Stela,

          I am sorry to hear about your daughter not well. this is a terrible disease.

          I didn’t go though Dr borody for the FMT I went on a clinical trail I add the link to the trail below http://www.clinicaltrials.gov/ct2/show/NCT01896635?term=fecal+transplant&state1=PA%3AAU%3ASW&rank=1

          after doing FMT for 8 weeks my sigmoscopy showed that I have significant improvement in my colon, but I was still symptomatic that is still go 5=8 times a day sometimes.

          since stoping treatment about 2 months now I get small flare ups. I think the FMT helps but you have to have a good donor and I think some people get good outcome others have to continue treatment. I also add link to another site were you do FMT at home
          thepowerofpoop.com
          I hope things improve for your daughter do take care.

  7. TeriDecember 25, 2012 at 1:56 pm #

    I did a home fecal transplant about 7 weeks ago after being on the Specific Carbohydrate Diet since May. I had two horrible months of flare during September and October and then in November did the FT.

    I have had normal bowel movements since then, with no gas, no cramps, no blood, no mucus. I highly recommend trying a fecal transplant. As horrible as I felt, I knew it couldn’t get much worse as I was down to 95 lbs.

    After the FT, had no bowel movement for 2 days then it just got better and better – I am still eating SDC foods (no foods containing sugar, starch, gluten, wheat,) for now but I feel great – gaining weight too. It feel GREAT to feel normal again!!!

    Read more here – http://healed-from-uc.blogspot.com/2012_11_01_archive.html

    There IS hope for healing and it doesn’t come from the prescriptions they give you as they only turn off your immune system.

    Teri

  8. Matthew A. A.July 22, 2013 at 6:57 pm #

    Hi. I intend to do a home FT within the next week or so. However, my one good donor is on monthly injections of Testosterone. He is a pre-op transgender. Female to male. I was wondering if that could somehow complicate using him as a donor? What little I could find on the subject didn’t suggest that it would. I just wanted a little feedback before I proceed. He really is my best bet. His general health, diet, and age(29, the same as mine), make him a good contender. Also, do you think I should have his feces tested to be safe(just in general). If so, how exactly should I go about that, and what might the costs be? Even an educated guess would help. One last question… Is it possible to freeze samples for home use? Taking the necessary(sanitary) precautions of course. Or would that kill/harm the bacteria?

    • AdamJuly 22, 2013 at 8:24 pm #

      All good questions Matt, I myself don’t have a clue as to answers for you there though. Good luck buddy, if you are working with a physician on this whole program, I’d be interested in what he/she would have to say about your questions as well. best of luck,
      Adam

      • Matthew A. A.July 23, 2013 at 7:12 am #

        Thanks for the quick response. My doctor actually knows less than I do about this subject. A lot of doctors don’t seem to know much about this area. And what they do know, usually isn’t beyond what I’ve learned through diligent research over the past six months. Even when she pursued it she couldn’t find basic nutritional information for a colitis diet(which I found easily). But I do intend to run the rest of this by her and work out the details. Even though I may be teaching her more than the other way around. I will keep you posted if any useful information comes out of this. Thanks to people like you my colitis has become more manageable. I really appreciate what you’ve done.

  9. Tom COctober 13, 2013 at 6:29 am #

    Would FMT help those w/gut resection. ( Of course I want to try it ! )

    Small intestine connected to small length of large colon left for that purpose of connecting.

    Remaining exit tract natural , rectum etc.

    Same constipation exists as before the surgery, sibo test indicate no overgrowth

    Small bowel follow through : normal, although the prep took as long to go through last few inches as whole preceding small bowel.

    Thank you !

    • TaraJanuary 14, 2014 at 4:17 pm #

      I would love to know the answer to this, as well. I have no remaining colon, however, but an ileostomy. Breath test came back a flatline; Dr. Mark Pimentel said “there’s no doubt you have SIBO.”

      My Crohn’s has been in remission since 1992, when I received my ileostomy. Since then, it’s been candida, bacterial overgrowth, leaky gut, inability to tolerate oxalates (lots of abx over the years) and probiotics, and doctors telling me I need an antidepressant. I now tolerate three foods.

  10. Amy HOctober 28, 2013 at 7:34 pm #

    I was wondering, in using FMT for C Diff, would a donor be disqualified because of having Strep throat in the past? Does strep live in the intestines?

  11. M. GonzalezMarch 17, 2014 at 6:27 pm #

    Robert Orenstein, DO, Mayo clínic on Arizona. You can find more inf. about him at mayoclinic.org. He is another doctor who perform the FMT procedure.

  12. AnneabellApril 24, 2014 at 3:28 am #

    Hi all I thought I let you all now I’m currently participating in a double blinded FMT trail. This trail goes on for 8 weeks, I’ve had my first infusion yesterday via a colonoscopy, in hospital then I give myself an enema 5 times a week I have been given frozen enemas which I defrost prior to giving myself my own fmt enemas now as this is a double blinded trail no one knows if I am being treated with the placebo or the fmt infusion, but after 8 weeks I will know if I have placebo I am given opportunity to go on the fmt treatment which, means that another 8 weeks of infusion s, I will let you all know how all goes and keep you all updated

    • AndreaJune 16, 2014 at 8:07 am #

      Annabell,

      do you have some news regarding your FMT? Did you have some positive result?

      i am italian and I would like to test this method.
      pls kindly write to me at: adglor(et)gmail.com

      regards

    • ankurSeptember 29, 2014 at 10:28 pm #

      hi anneabell
      waiting to hear from about the response you got post fmt..
      have a good time

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