Xeljanz (Tofacitinib) Medication for Ulcerative Colitis

XELJANZ® (tofacitinib) for the Treatment of Moderately to Severely Active Ulcerative Colitis

tofacitinibOn May 30th, 2018, the Pfizer corporation, announced that the Food and Drug Administration (FDA) has approved its application to allow for Xeljanz to be used by ulcerative colitis patients who meet certain criteria.

There are some more details listed on the Pfizer website about this new medicinal product of theirs.  You can read the full press release here:  https://press.pfizer.com/press-release/pfizer-announces-us-fda-approves-xeljanz-tofacitinib-treatment-moderately-severely-act

What would be excellent is for the current and future UC’ers of the world who have experience with Xeljanz (Tofacitinib) to start including their reviews of this on this page, both reviews of how it went, and as well any potential side effects.

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Side Effects
Other Meds
Xeljanz (Tofacitinib)
Prednisone 10 mg
December 25, 2018
Xeljanz (Tofacitinib)
Prednisone tapered to 7.5 mg
November 28, 2018

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Xeljanz - Tofacitinib
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6 Responses to Xeljanz (Tofacitinib) Medication for Ulcerative Colitis

  1. Marty Vaughn September 7, 2018 at 4:44 am #

    Has anyone taken 6-MP for UC? It had not been approved by the FDA for the use for UC. It is used for leukemia.

    • Jo Ann Guagliardo September 15, 2018 at 12:30 pm #

      I was taking 6 MP for 8 years for UC. I stopped taking it about 10 years ago because it is a medicine to treat leukemia…and also because I needed to always get blood work done to check my white blood cell count. I am currently in remission.I have had UC for at least 34 years.

    • JANET CRAWLEY September 23, 2018 at 10:28 am #

      I took it for about 6 years. It worked ok. Reducing my flares to about one a year. I have mild to moderate UC.
      I had no side effects. It seemed to stop working after 6 years so dr took me off and put me on Apriso.
      I have been on Apriso for at least 10 years. No side effects. One flare a year. Seems that’s what most meds do for me but it’s better than being flared all the time.

  2. LWT January 8, 2019 at 10:11 pm #

    Starting Zelganz in a few days. In the middle of my worst flare ever. So I’m currently on 60 mg of prednisone and asacol. I have tried entivyo w/o much response and recently remicade. I responded during the loading doses and 1 post loading dose. I couldn’t make it the full 8 weeks. Unfortunately my health insurance, BCBS, doesn’t allow remicade dose increase or increase in frequency so off to try Zelganz I go.
    This time I’m also beginning a gluten free and no-low sulfite diet.

    Any other people try this yet? Not excited about the laundry list of side effects.

    • sbeckham March 2, 2019 at 11:48 pm #

      My GI is recommending that I try Xeljanz since Entyvio is no longer reducing inflammation. I also am not excited about the laundry list and the high out of pocket cost for this very expensive drug since my insurance minimally covers it. Have you had positive results since you started it in January?

  3. LWT March 5, 2019 at 8:52 am #

    Actually I am responding very well and absolutely no side effects. I started xelganz on a prednisone bridge, and I’m still titrating off of the prednisone. Down to 10mg and still doing well, which means the xelganz is doing the heavy lifting.
    There is a manufacturer coupon for xelganz- it buys down your co-pay, go to the website. Also ALL the GI’s have samples- so you can try it before you buy it.
    I do like the ease of a pill vs: scheduling an infusion.

    My GI is monitoring me closely though, labs every two weeks, my luekocytes are still a little low, but you can’t have it all lol!

    FYI…I responded better to remicade then entyvio, so maybe you can try that first if it’s covered by your insurance?

    Best wishes!

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