Hey UC’ers,
A new study was recently published that detailed some pretty fascinating results regarding fecal transplant therapy for people with UC.
It was conducted in China at one of their Gastro Disease centers and I want to share some of their results with you in this post and of course you can read the full study details here at anytime.
The study was titled: “Step-up fecal microbiota transplantation strategy: a pilot study for steroid-dependent ulcerative colitis”
Background:
The strategy of using fecal microbiota transplantation (FMT) for refractory ulcerative colitis (UC) remains unclear if single FMT failed to induce remission. This study aimed to evaluate the efficacy and safety of a designed step-up FMT strategy for the steroid-dependent UC.
Results of the Study:
Eight of fourteen (57.1 %) patients achieved clinical improvement and were able to discontinue steroids following step-up FMT. One patient was lost to follow-up. Among the 8 patients who responded, five (35.7 %) received one FMT therapy, one (7.1 %) received two FMTs, and two (14.2 %) received two FMTs plus a scheduled course of steroids. Four (28.6 %) of the 8 patients who responded maintained long-term remission during follow-up (3–18 months). Six patients (42.9 %) failed to meet the criteria of clinical improvement and maintained steroid dependence, though three experienced transient or partial improvement. Microbiota analysis showed that FMT altered the composition greatly, and a microbiota composition highly similar to that of the donor emerged in the patients with successful treatment. No severe adverse events occurred during treatment and follow-up. ***(This was one of my favorite parts of the details listed of this study!! No severe adverse events occurred….!!! that’s some good news folks!)
Conclusions:
Step-up FMT strategy shows promise as a therapeutic strategy for patients with steroid-dependent UC, likely due to the successful restructuring of gut microbial composition.
Again, you can read the full results of this study at this link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567790/
Feel free to posts any thoughts you might have on this one! And if you are one who has some experience yourself with FMT for your UC, please share a comment on how it has gone for you!
And have a great day,
Adam
there is a section of the site devoted to FMT stories that you flip through here: iHaveUC FMT Stories
I started site shortly after being diagnosed in October of 2008 with severe pancolitis (when my whole colon was inflamed).
For me, it was a very rough start with severe symptoms. Getting bounced from medication to medication was not easy or too helpful. But, I did meet another UC’er, changes several parts of my diet, and of course the rest is history.
Leave a comment, ask a question, take advantage of our past experiences here, use the search boxes, they are your friends to0:)
I’ve written 2 different ulcerative colitis ebooks, you can check them out here.
And, the Free eNewsletter, which has important updates can be joined here.
