Well, this month marks my 10th anniversary since my first flare-up of pan colitis. I remember how scary that was – not knowing what was wrong. It’s hard to believe that it’s now 10 years later and I am about to take my 24th and final dose of methotrexate this week and I have to say that it has really helped my UC. I began back in September by injecting 25 mg of methotrexate subcutaneously once a week. After the first 12 weeks, I had a colonoscopy and it showed healing. The doctor had me change the dose to 15 mg for the next 12 weeks and then stop. I have been feeling good lately (knock on wood). Reduced trips to the bathroom now – only 3-5/day. I think I am either in remission or as close to it as I have been since 2005. I’ve even regained the ability to pass gas without fear of sharting my pants – much to my wife’s chagrin. I am definitely no longer at the point of considering surgery. The question now is what happens once I finish the course of meds. Will I stay this way, or get worse? We’ll have to wait and see. I am definitely glad I tried it. Giving yourself the injections is not difficult at all. The worse part of the whole thing is going to the lab every 2 weeks to get your blood work done. I would recommend this treatment to anyone that is not getting results from other treatments. Current meds: Apriso, methotrexate, remicade, rowasa, cortenema, and lomotil.