Pentasa (also know as Masalazine or Mesalamine) is a relatively common medications that is prescribed for ulcerative colitis patients. Pentasa is within the family of 5-aminosalicylic acid (5-ASA) drugs, and it is used as an anti-inflammatory medication which is targeted specifically for people with inflammatory bowel disease.
There is tons of information available online with regards to published studies on medications in the 5-ASA family.
Some recent studies:
- Long-Term Mesalamine Maintenance in Ulcerative Colitis: Which is More Important? Adherence or Daily Dose.
- Medication use patterns and predictors of nonpersistence and nonadherence with oral 5-aminosalicylic acid therapy in patients with ulcerative colitis.
- Mesalamine in the treatment and maintenance of remission of ulcerative colitis.
- Exacerbation of bloody diarrhea as a side effect of mesalamine treatment of active ulcerative colitis.
- Mesalamine-induced myocarditis and coronary vasculitis in a pediatric ulcerative colitis patient: a case report.
- 5-ASA Dose-Response: Maximizing Efficacy and Adherence
Search Side Effects Below:
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Exacerbated colitis. Increased diarrhea and bleeding, severe rectal pain. Side effects of the drug were worse than the colitis.
January 2, 2017
Muscle cramping in leg and cramping in bowel, I have reduce the symptoms of this by taking magnesium supplements.
November 12, 2016
Bad abdominal pain, diarrhoea
October 25, 2016
August 22, 2016
August 15, 2016
August 9, 2016
August 8, 2016
My hair thinned noticeably. I was taking 4, 500mg tablets twice a day. It grew back eventually on stopping Pentasa.
August 7, 2016
On it for two now getting sore joints
August 7, 2016
Prednisone. Agitation, Trouble sleeping, hyperactive, Trouble focusing
July 28, 2016
Eye pain & chest pain when breathing. Never had either of them before the medication and they both disappeared when I stopped taking it.
July 24, 2016
If you have taken Pentasa be sure to share your experience with the medication by submitting your review below:
I am allergic to sulpher based drugs. The hospital knew this yet they still gave me Pentasa. After being on the SCD for 4 years with no UC symptoms I was told by an arrogant specialist that the diet was very very bad and I had to take Pentasa or I would get colorectal cancer. Pentasa sent my bowel into a spin. Within 24 hours I felt like crap and my bowel motions had turned to what resembled dry, green tea leaves floating in the water. I stopped taking it but he had scared me so I kept taking it on and off. It didn't matter. The damage was done. I progressively got worse until I ended up in hospital. This is after never having a flare or taking any drugs for 4 years on the SCD. A colonoscopy showed that 35cm of my bowel was inflamed. The other 5 feet was 'unremarkable'. In other words normal. Three months later a colonoscopy on my second return to hospital revealed that my entire colon was in a raging mess. They called it a flare. I'm calling it war with Pentasa. I could not believe the state my colon was in. My colon was removed and I was given an ileostomy and told it would be reversed when I was in better health. I nearly died. Now I find out that 30 to 40% of people who have the reversal done after removal of their colon find that they are housebound and have no social life so come back asking for the bag again. This is ridiculous. The medical profession have a lot to answer for. They have ruined my life.
I had 3 ulcer attacks in 1 month worst ever finally got back on ascol have not had attack yet. Pentagon did not work for me also had thinning hair
Pentasa enema highly recommend
I have had UC for 7 years and am currently on a combination of medications. I use pentasa enemas once or twice a day (I aim for twice but it's not always possible). I think they are great because the liquid goes directly to the inflamed area (similar to putting cream on the inflamed skin for eczema).
For the last 2 years I have been on methotrexate medication. I thought that this was to replace needing the mesalazine and pentasa medication so, as I was keen to reduce taking any unnecessary drugs, when I was feeling well I stopped taking them. Within a week I noticed my UC getting much worse (running to the toilet, stomach cramps). Using the pentasa enema quickly lowered the inflammation again - within a week.
Taking pentasa enema does keep all your BM pretty runny - I expect because it is putting so much liquid in to your bowel area. It also flushes out that area so I don't have much solid poo when using it - but I am not sure that I would anyway because my UC still has a low level of inflammation.
I find that when I eat this shakes up my digestive system and makes me need to pass BM. I take loperamide (Immodium) 1 tablet daily on week days and this stops me needing the toilet during the day as well as making less gas build up. I didn't do this for years as I didn't realise you could until the hospital pharmacist suggested it. I now get loperamide on prescription.
Pentasa enema comes in massive boxes so it is best to get it at a pharmacy with a car park that you can drive to. The pharmacist will carry it to the car for you if you are not feeling well.
I am not aware that I have any side effects from taking mesalazine and pentasa enemas.
I was diagnosed with UC about 6 years ago and, due to a slew of other medications for liver transplant and GIRD, was loathe to take yet a further, rather large, tablet. So I opted for the 1gm granule sachet, which I take twice a day. Unless I am really silly with my diet it keeps the UC at bay and I have had only one or two bad flare ups since being diagnosed. I have never passed blood but did pass mucous before I was put on to the medication. Unfortunately I have rapid metabolic disorder so I find I still use the loo about 4-5 times a day, but the stool is not loose. Apparently I have been cursed with a number of auto-immune disorders and I wonder if any other UC sufferer has a further auto-immune disorder?
Unbeknownst to me, Asacol and Pentasa are in the same family of drugs. That means when I started to feel anxiety as a side effect of Asacol and my doctor switched me to Pentasa the anxiety just continued to get worse.
My stomach was fine, but the anxiety I felt was debilitating.
I had a severe flare up of uc and went to the va. I was treated with iv prednisone until the bleeding stopped. The md insisted I go on mesalamine , not prednisone due to the side effects of prednisone. The only thing good about mesalamine was I didn't bleed, but the diarrhea at unwanted times, and it's volume continued . I also suffered severe stomach pains at all times. I returned to the va and was given prednisone but for only 3 days at which time I was to return to the md for his advice. I heard from his secretaries he only prescribed mesalamine. I searched out a private md and received prednisone which works %100 of the time on %99 of patients. I got my quality of life back. I attempt to go below 20mg/day every month and this reduces the side effects. Melasamine and humira kill some patients. Prednisone does not, and prednisone is cheap and time tested. Don't waste your time with mesalamine. If you don't have a flare up for a while, it is just due to luck. Patients go into remission at different times. If you are on a med it is not due to the meds. Prednsione does stop flare ups and allows you to go to work, drive your care with confidence.
I have total pancolitis diagnosed 7 months I also have type 1 diabetes, graves disease and Addisons disease. I have been using 8times 500mg of pentasa since I was diagnosed I was also on prednisolone for 4 months which helped but has nasty side effects, I'm concerned about pentasa as I told my gastroenterologist I am having a flare up diahorrea 20 times a day he said it could be a side effect from pentasa? He hasn't changed my meds yet as he's not sure what I can have with all my health conditions.
Pentasa completely cleared up my first ever flareup within a few weeks. It cleared the next one too, and the one after that. It worked so well that I think I got cocky, I barely altered my diet and only cut out the most egregious offenders such as fizzy drinks. Pentasa continues to work well and had me in remission even while my diet was absolutely terrible(way too much sugar), but I may be becoming more resistant to it as I am in a severe flareup currently.
I have had no side effects from this drug, and recommend trying it to anyone who is not allergic to mesalazine.
When I first began taking Pentasa I was having more diarrhea. However after a few weeks this stopped and I can honestly say it has really helped my Crohns and I now go to the loo twice a day instead of 10 times a day. I am taking 2g daily (4 tablets x 500mg twice a day) WITH food. It has really helped me so far so I am glad I gave it time to settle down
I'd like to add to what has been said in other posts regarding sulphur allergies and pentasa - I only took 2 doses of pentasa (about a month apart because of its side effects) and both doses seemed to exacerbate my symptoms. Prior to the first dose my symptoms were relatively minor (actually only proctitis on scope) but within 2 months of the 2nd dose I was admitted to hospital with fulminant pan-ulcerative colitis. I did not respond to prednisone but did to a dose of infliximab. Had I not responded surgery was the only option remaining. While Pentasa may not have been the sole cause of my 'flare' (it's hard to rationalise how a suppository might affect the whole colon so quickly) I believe that it is worth being cautious if you know you have a sulphur allergy.
I had the worst time on pentasa, I vomited every twenty minutes, and couldn't stop going to the loo. mezavant was awful too, and on asacol I lost a stone in a week
Just a warning about Pentasa, Asacol, and any other 5asa drug. If you are allergic to sulfa drugs (5 asa drugs are a relative to sulfasalazine) the side effects of these drugs will be to exacerbate your symptoms. My son was diagnosed with Crohn's because of a peri-anal fistula. He had no other symptoms aside from the fistula but was put on Asacol and then Pentasa in anticipation of future symptoms. Well, he got them alright. Diarrhea, vomiting, abdominal pain. That prompted a year of prednisone cycles and experimentation with Imuran (bad for him) and finally led him to Remicade. Only after a year did we realize he was allergic to sulfa drugs, purely by accident. We had a doc suggest trying the pure form of sulfasalazine, and he broke out in hives, so we realized he was allergic to those meds. Then, when reviewing the chemical make up of Pentasa (which he was still taking) we realized it was related to sulfasalazine and says right in the warnings that it will cause Crohn's symptoms if taken by someone who is allergic to sulfa drugs. Our doctors didn't even know this. Once we took him off Pentasa, diarrhea, vomiting and abd. pain all went away. Unfortunately, since he was pre-puberty, doc recommended we stay on Humira until he's through just in case he gets a flare, they don't want him taking any more prednisone.
i prefer to use pentasa sachets 1gram instead of 2 tables 500mg from 2 or 3 times which means will take 6 tablets. this from psychological point better. and when i was on tablets i didn't notice improvement. but when changed to sachets i become got more relaxation. also i took sepralx tablets which improve the mood status. it helped me alot.
Three reviews for this so far and all from New Zealanders. Must be something in the water...
I have been taking this 4 times a day for the last 6 months. I have mild UC and find it does the trick to keep the symptoms down. I too was told by my doctor to lower the dosage to 2 pills a day recently, but found when I did that I started getting bloody stools again. So I went back to 4 a day.
I had a blood test recently and found my testosterone levels have lowered since taking this, not a pleasing side effect.
Pentasa gave me freedom
I was prescribed Pentasa when I was first diagnosed, in 2000. I started on four tablets a day, at one stage increased to six, but for the last two years have given myself a "maintenance" level of two a day because my UC is more or less in remission. My specialist advised I could give it away altogether, but when I tried this, I had a flare-up. On a minimum dosage, I have very few symptoms and have basically got my life back. I've had no side-effects and my specialist has told me it's a very safe medication. I have noticed that he is very interested in my diet now (wasn't 10+ years ago)and I do eat a lot more vegetables and fruit than I used to, which I think has also helped.