New Ulcerative Colitis Medication: “Vedolizumab” the Integrin Antagonist

There has been some recent news breaking the airwaves/internet waves I guess is more accurate about some clinical study data which you may find impressive. The name of the medication behind all the hype is Vedolizumab. Whether it’s marketing or not is up to you to decide, but many of the news articles and published studies are describing it as a “new class” or form of medicine. Take for example Colazal or Asacol, or Pentasa, those three medications might have been described by your doctors as being in the “5-ASA” class of drugs. Then you have other drugs like Humira and Remicade which may have been described as “Biologics”. Anyways, Vedolizumab is part of the (or starting since I have not heard of any others yet) “Integrin Antagonist” class.

What’s New with Vedolizumab?

Below, please feel free to read as much as you like about this new medication, I’ve included several links to studies from PubMed which go into some nice details about Vedolizumab.

But generally speaking (and I’m sure some immunologists can take this WAY further), this medication is different from some other “immune suppressants” in that it does a much better job of targeting specific parts of the immune system related to the colon and ulcerative colitis symptoms.  If you step back a minute and think of our bodies as a whole…well that’s a huge complex massively complicated group of many different systems working 24/7.  Within our bodies we of course have our immune systems.  And within our immune systems we different sub-systems.  With UC, we often think of the inflammatory response.  So, to simplify the thinking, lets assume that Vedolizumab does a better job at targeting specific parts of the inflammatory response compared to some other medications.  (That is at least a major part of the marketing that Takeda which is a massive drug company is explaining to the FDA in hopes of gaining approval.)

So again, please do some more reading on this medication if you find it interesting.  I’m not big into medications myself, but they are successful for many UC’ers and that’s what this info-share is all about.

Vedolizumab links you may find interesting:
•    My favorite diagram showing how this is different & how the drug works: diagram picture
•    New and emerging treatments for ulcerative colitis: a focus on vedolizumab – PubMed Free article
•    Vedolizumab – Wikipedia link
•    Vedolizumab for the treatment of ulcerative colitis and Crohn’s disease – Free PubMed article

If any of you have first hand experience with a clinical trial and would like to share a “review” of your use of Vedolizumab (assuming you did not receive the placebo…) feel free to add that below.

Takeda has stated that this is the world’s largest clinical trial for IBD EVER…  And, it seems that a major goal of this medication is to come up with another immune suppresant related therapy which hopefully will have less side effects when compared to its peers.  So whether or not your into western medicine, I think we can all agree that’s a nice goal to have.

Best of luck to all of you,

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Tags: Vedolizumab

16 Responses to “New Ulcerative Colitis Medication: “Vedolizumab” the Integrin Antagonist”

  1. bevAugust 22, 2013 at 3:05 pm #


    I just watched this on the Canadian news last night…very interesting…I wonder if there are side effects, and what the long term safeness might be. Too soon to tell, I guess.

    The guy on the news last night who is taking this new drug said that he was still feeling totally normal after 14 months, with no symptoms, and no side effects. I was pretty jacked, to say the least…

    I suppose time will tell.

    Thank you for everything,

    • AdamAugust 22, 2013 at 8:18 pm #

      You be for sure right, we’ll have to wait and see how all turns out.

      HOpeufully it works for many upon many though!!

      • Tony .MNovember 16, 2013 at 5:12 pm #

        Hi Adam, Do you know if this medication is or will be available in Australia??? Where
        can I find out more information about it as I have a child who has Crohns

        • AdamNovember 17, 2013 at 4:56 am #

          HI Tony,

          I don’t know about the current availability in Australia. But, best bet would be to contact your local GI doctor, and inquire with them. I would hope they would be able to assist you right away.

          (Also, be sure to find the company’s website online who manufactures the product, as there are often different “brand” names used in countries which vary from place to place)

          best to you,


  2. bevAugust 22, 2013 at 3:05 pm #

    …oh, and it won’t be available in Canada for one to two years, apparently….

  3. MattSeptember 8, 2013 at 7:47 pm #

    My doctors are very excited about this new drug. They said it will change the face of UC. I’m not as optimistic but I hope they are right. My doc says the side effects are close to 0! What?! They claim it will be out in March 2014. 1 of the many trails are being done here in Chicago.

    • bevSeptember 9, 2013 at 5:51 am #

      Zero side effects would be great! I hope this is true…I still think FTs…(good bacteria) is the real way to knock UC into remission. No drugs is my wish and goal for the future of treating UC!!

      Cheers all :)

  4. MattSeptember 15, 2013 at 1:04 am #

    Bev I feel the same! FT has to be the way. I tried it at home and it didn’t take, I’m hoping this is more acceptable in the medical community very soon. I’m seeking a different donor


    • bevSeptember 15, 2013 at 8:31 am #

      Let’s hope it’s soon, Matt.

      Any idea why the FTs didn’t ‘take’? Were enough of them done? It’s different for everyone. Some people need more than others. Also, you said you may need a different donor? I never considered that before, but perhaps some people do carry and have more good bacteria than others? This is all so interesting…and complex…

  5. amyNovember 9, 2013 at 1:14 pm #

    I want to try this medication!! Anyone know if the FDA approved it yet. According to what I read, i believe it’s been submitted for review (sitting on a desk somewhere at the fda).
    regarding FT’s – they now have a new way of introducing the bacteria into the body – pill/capsule form (i know it sounds gross, just dont think about it lol)

  6. ColNovember 9, 2013 at 4:31 pm #

    It’s up for FDA review on December 9 of this year. It’s been given priority status. And it looks like the name might change to Entyvio. Here’s hoping it’s everything they’re saying it is!

  7. M. GonzalezFebruary 6, 2014 at 5:21 pm #

    What drug are you talking about?

    • AdamFebruary 6, 2014 at 7:12 pm #

      it’s called: Vedolizumab

      • M. GonzalezFebruary 6, 2014 at 8:13 pm #

        Thanks. I am on Remicade. Feeling better but having side effects like allergies and fatigue. I read that this new drug could be more dangerous to people that are taking Remicade or Humira. Do you have information about it?

        • AdamFebruary 6, 2014 at 8:17 pm #

          No, I’m sorry I don’t

  8. RickMarch 15, 2014 at 7:24 am #

    Diagnosed with distal UC in 2010, and have had one serious flare that landed me in the hospital for a week last year, due to an allergic reaction to colozel. I’ve been on no medications and have largely followed the specific carbohydrate diet. Still, I have bad periods that restrict my lifestyle. A drug that promises to work with minimal side effects would be one I’d be willing to try.

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