There has been some recent news breaking the airwaves/internet waves I guess is more accurate about some clinical study data which you may find impressive. The name of the medication behind all the hype is Vedolizumab. Whether it’s marketing or not is up to you to decide, but many of the news articles and published studies are describing it as a “new class” or form of medicine. Take for example Colazal or Asacol, or Pentasa, those three medications might have been described by your doctors as being in the “5-ASA” class of drugs. Then you have other drugs like Humira and Remicade which may have been described as “Biologics”. Anyways, Vedolizumab is part of the (or starting since I have not heard of any others yet) “Integrin Antagonist” class.
What’s New with Vedolizumab?
Below, please feel free to read as much as you like about this new medication, I’ve included several links to studies from PubMed which go into some nice details about Vedolizumab.
But generally speaking (and I’m sure some immunologists can take this WAY further), this medication is different from some other “immune suppressants” in that it does a much better job of targeting specific parts of the immune system related to the colon and ulcerative colitis symptoms. If you step back a minute and think of our bodies as a whole…well that’s a huge complex massively complicated group of many different systems working 24/7. Within our bodies we of course have our immune systems. And within our immune systems we different sub-systems. With UC, we often think of the inflammatory response. So, to simplify the thinking, lets assume that Vedolizumab does a better job at targeting specific parts of the inflammatory response compared to some other medications. (That is at least a major part of the marketing that Takeda which is a massive drug company is explaining to the FDA in hopes of gaining approval.)
So again, please do some more reading on this medication if you find it interesting. I’m not big into medications myself, but they are successful for many UC’ers and that’s what this info-share is all about.
Vedolizumab links you may find interesting:
• My favorite diagram showing how this is different & how the drug works: diagram picture
• New and emerging treatments for ulcerative colitis: a focus on vedolizumab – PubMed Free article
• Vedolizumab – Wikipedia link
• Vedolizumab for the treatment of ulcerative colitis and Crohn’s disease – Free PubMed article
If any of you have first hand experience with a clinical trial and would like to share a “review” of your use of Vedolizumab (assuming you did not receive the placebo…) feel free to add that below.
Takeda has stated that this is the world’s largest clinical trial for IBD EVER… And, it seems that a major goal of this medication is to come up with another immune suppresant related therapy which hopefully will have less side effects when compared to its peers. So whether or not your into western medicine, I think we can all agree that’s a nice goal to have.
Best of luck to all of you,